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Cancer: Gut microbiome provides prognosis for therapy
Cancer patients respond differently to therapies. Our latest research has found that the success of the classical treatment methods depends on the composition of the microbiome in the gut, in particular several key specific bacteria.
Autophagy mediates evasion of bacterial missiles by mediating the release of decoy flares
Many disease-causing bacteria secrete pore-forming toxins that target the plasma membrane of host cells. We uncovered a counter defence response by the host involving the release of extracellular vesicles, defensosomes, downstream of innate immune activation of autophagy proteins.
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