Nature Comms

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HPV circRNAs: Transformation with no end in sight

Although circular RNAs (circRNAs) are abundant and can be encoded by viruses, the function of most circRNAs remain unclear. We describe the discovery of circRNAs in human papillomaviruses (HPVs) including a circular E7 RNA (circE7). CircE7 is translated and required for transformation in cervical cancer cells, providing strong evidence that circRNAs can be translated and have important biological functions. Jiawei Zhao Richard Wang
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Jun 11, 2019