Declines in HIV incidence among men and women in a South African population-based cohort

Southern Africa is the region with the world’s highest rate of new HIV infections. Over the last decade, there has been a multi-million-dollar investment in antiretroviral therapy to prevent the onward transmission of HIV and bring the epidemic under control.

Go to the profile of Alain Vandormael
Dec 13, 2019
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As a post-doctoral researcher, I held several assumptions about how the unprecedented scale-up of antiretroviral therapy (ART) would impact the incidence of HIV in a hyperendemic South African setting (Figs. 1 & 2). These scale-up efforts included novel strategies to empower women and remove the structural barriers to ART uptake, barriers such as lack of education, poverty, sexual violence, and gender inequality.1 When I began my research in 2016, I therefore assumed that the earliest and largest declines in HIV incidence would occur among women. To the study team’s surprise, we observed the opposite. 

Fig 1. A snapshot of the study area in the KwaZulu-Natal province of South Africa. The community is at the epicentre of the global AIDS epidemic, with one in every two women (aged 35–49 years) infected with HIV. To measure trends in incidence before and after ART scale-up, we repeatedly tested 22,000 uninfected men and women for HIV between 2005 and 2017.

We found that ART uptake was indeed higher among women, but this translated into larger declines in HIV incidence among men. In fact, male incidence was the first to decline between 2012 and 2017, from 2.5 to 1.0 new infections per 100 person-years—a reduction of 59%. This reduction was markedly higher than the 37% decline among women, from 4.9 to 3.1 new infections per 100 person-years between 2014 and 2017 (Fig. 3). How can these unequal declines in HIV incidence be explained? 

Fig 2. The Africa Health Research Institute (AHRI) maintains one of the world’s largest and longest running population-based HIV cohorts, with around 3,000 directly observed infections over 90,000 person-years of follow-up. Trained field-workers visit all 11,000 households in the study area to collect dried blood spots from participants (older than 15 years) for HIV testing. These uninfected participants are repeatedly tested for HIV, which is the gold-standard for estimating the incidence rate.

One explanation is that once women achieved higher ART coverage and hence lower levels of detectable viremia, they were less likely to transmit HIV to their uninfected male partners. In the study area, as well in the broader sub-Saharan African region, the predominant mode of HIV transmission is through heterosexual intercourse. Plausibly, male HIV incidence declined first because women were the first to achieve a critical threshold of ART coverage in 2012 (Fig. 3).

Another explanation is that HIV-uninfected men benefitted from the scale-up of voluntary medical male circumcision services. Between 2009 and 2016, there was a steady increase in male circumcision coverage, from 3% to 33% (Fig. 3), mainly due to a decree by the Zulu King, in consultation with the local Department of Health, that all Zulu men in the study area be circumcised.2,3 Circumcision uptake, which can reduce male HIV risk during sexual intercourse,4 is likely to have contributed to the earlier and larger reductions in HIV incidence among men. 

Fig 3. The figure shows trends in HIV incidence, self-reported condom use, self-reported male circumcision, opposite-sex ART coverage, and opposite-sex prevalence of detectable viremia (i.e., the amount of detectable virus in the blood). We show that male HIV incidence began to decline after 2012, following increased male circumcision coverage, female ART coverage surpassing 35%, and a decrease in the female prevalence of detectable viremia. Declines in female HIV incidence after 2014 correspond with male ART coverage reaching 35% and declines in the male prevalence of detectable viremia.

Our study findings reminded me of a paraphrased quote from my PhD dissertation: “what happens inside the body may be a biological matter, but HIV’s journey between bodies in blood and semen is both biological and social.”5 Biologically speaking, the unequal declines in HIV incidence are consistent with what we already know about the preventative benefits of ART and male circumcision. But it is the social aspects—the program strategies to increase ART uptake among women and a Zulu King’s decree for male circumcision—that led to our unexpected results. Getting more men onto consistent, suppressive ART needs to be part of the broader public health response, so that new HIV infections can be reduced among women.


References

1         See for example: PEPFAR (President's Emergency Plan for AIDS Relief) and DREAMS (Determined, Resilient, Empowered, AIDS-free, Mentored and Safe). https://www.usaid.gov/global-health/health-areas/hiv-and-aids/technical-areas/dreams

2         Sithole B, Mbhele L, van Rooyen H, Khumalo-Sakutukwa G, Richter L. Only skin deep: limitations of public health understanding of male circumcision in South Africa. South African Med J 2009; 99: 647.

3         KZN Department of cooperative governance and traditional affairs. Zulu Monarch calls for more men to undergo circumcision. 2018. http://www.kzncogta.gov.za/zulu-monarch-calls-for-more-men-to-undergo-circumcision/.

4         Kong X, Kigozi G, Ssekasanvu J, et al. Association of medical male circumcision and antiretroviral therapy scale-up with community HIV incidence in Rakai, Uganda. JAMA 2016; 316: 182–90.

5         Heimer, C. Old inequalities, new disease: HIV/AIDS in sub-Saharan Africa. Annu. Rev. Sociol. 2007, 33:551–577.

 




Go to the profile of Alain Vandormael

Alain Vandormael

Group Leader, Heidelberg Institute of Global Health, University of Heidelberg

I am a Group Leader in the Heidelberg Institute of Global Health at the University of Heidelberg, Germany. My academic interests include population health, epidemiology, and statistics, with a focus on HIV-related outcomes. Specifically, my research seeks to understand why some HIV prevention strategies in sub-Saharan Africa are falling short, and provide insight into how these strategies can be optimized in the future.

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