The microbiome is everywhere, including in our birth plan

If your child is delivered by C-section, will you restore his/hers microbiota?

Go to the profile of Claudio Nunes-Alves
Feb 02, 2016
2
2
Upvote 2 Comment

When a microbiologist and an immunologist discuss their birth plan, the microbiota isn't left out. Ok, maybe not always, but at least not in our home, where dinner table talk commonly revolves around the links between microbes and immune cells. We're expecting a baby boy in a couple of months, so it is starting to feel real, and in a few weeks we do need to talk to our midwife about our birth plan. There are tons of things that the NHS tells you to think about, but the microbiota isn't one of them. But one of the items in that long list is the mode of delivery, and I was actually surprised to find out that, in the UK, 1 in 4 births occurs via a C-section (although this varies widely across Europe). Now, there has been no formal causation demonstrated between C-section birth and health problems later in life, but there are epidemiological studies that point to an increased risk of immunological and metabolic disorders, including asthma, allergies and obesity. And even though the cause(s) are unknown, we feel that this could be influenced by the microbiome, which has been shown to differ between infants born vaginally and infants born by C-section: the microorganisms found in the first group resemble those found in the maternal vagina, whereas the composition of the microbiome of the second group is more similar to that found in mother's skin. Interestingly, Maria Dominguez-Bello and colleagues just published a microbial restoration procedure to colonize C-section delivered babies with the maternal vaginal microbiota. The procedure sound straightforward and involves swabbing the infants within the first 3 minutes after birth with gauze that was incubated in the maternal vagina for an hour before the C-section, starting with the mouth, then the face and finally the rest of the body. And even thought this doesn't completely restore the microbiome composition to what is found in vaginally delivered infants, it does provide partial restoration throughout the first month of life. The article describes 4 infants, and the authors acknowledge that their work "represents a proof of principle on a small cohort and with limited follow-up over time", but we think that, for now, this was sufficient and we'll definitely write it down in our birth plan, should a C-section come our way. And if it does, we may even get in touch with the authors, you never know if they need more samples.

Go to the profile of Claudio Nunes-Alves

Claudio Nunes-Alves

Senior Editor, Nature Microbiology

I'm a senior editor at Nature Microbiology, interested in all things bacteria, virus, archaea, fungi and parasites (but I mostly handled articles focusing on bacterial physiology, evolution, parasites and archaea). Before joining Nature, I studied biochemistry at the University of Porto, Portugal, as an undergrad; and was a grad student and post-doc in the labs of Margarida Correia-Neves (ICVS, Braga, Portugal), Sam Behar (Brigham and Women's Hospital and Harvard Medical School, Boston, MA, and then at UMass Medical School, Worcester, MA) and Christophe Benoist (at Harvard Medical School, Boston, MA), where I studied multiple aspects of immunity to tuberculosis.

2 Comments

Go to the profile of Andrew Jermy
Andrew Jermy over 1 year ago

Mrs @jermynation and I did something along these lines for our first born, although the timing of incubation and length to inoculation varied dramatically compared to the manuscript you note. And it is an experiment for which we will never know whether it had any effect,, at least to say that there were and aren't any obvious signs of harm for @jermynation junior. Interesting study, thanks for writing it up here Claudio!

Go to the profile of Andrew Jermy
Andrew Jermy over 1 year ago

"...for our first born..." should probably read "...only born..."