July 2017 cover
Linear ubiquitin recruitment to Salmonella mediates xenophagy and immune signaling. Image by Ella Maru Studio; cover design by Karen Moore.
Linear polyubiquitin patches in the Salmonella Typhimurium ubiquitin coat, regulated by E3 ligase LUBAC and deubiquitinase OTULIN, serve as a platform to modulate xenophagy, NF-kB signalling, secretion of pro-inflammatory cytokines and bacterial proliferation.
Refers to "Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation" by van Wijk et al.
"LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB" by Noad et al.