In the gastrointestinal tract, smooth swimming facilitates invasion of intestinal epithelial cells by Salmonella Typhimurium. We found that the master regulator HilD coordinates these processes and that McpC, a chemotaxis protein, promotes straight swimming and optimal invasion.
We often witness what objectively look like strange occurrences without giving them much (if any!) importance—in most cases, because we heard about them so many times that we take such observations for granted. One of them is the co-existence of two alternative glycolytic pathways in E. coli ...
Gut epithelial integrity is dynamically shaped by microbial signals amenable to environmental and psychological modulation. Here we dissect dietary impact on psychological stress-induced gut microbial remodeling and how this is metabolically linked to stem cell proliferation and epithelial renewal.
COVID-19 forced a suspension to our primary ciliary dyskinesia (PCD) diagnostic service. Re-purposing nasal epithelial cell RNAseq data and bioresource, three University of Southampton groups joined forces and found a new “short” isoform of ACE2, the cell surface receptor for SARS-CoV-2 virus.
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