Exploring the advanced material cultures 45,000 years ago in East Asia
An international team has reported Initial Upper Palaeolithic archaeological remains dating to 45,000 years ago from the Shiyu site in northern China. Shiyu is the oldest and easternmost site of its kind. The discovery reshapes our understanding of the timing and routes of human migration in Asia.
A potential patient stratification biomarker for Parkinson's disease based on LRRK2-mediated cellular alterations in peripheral blood
A recent study substantiates a role for increased LRRK2 kinase activity in some idiopathic Parkinson's disease patients and suggests that blood-based patient stratification approaches hold promise in nominating patients who may benefit from LRRK2-related therapeutics.
Pathogenic bacteria hijack probiotic signal to activate virulence factor production and promote its survival
Are probiotics effective in preventing infections? what is their efficacy in physiologically relevant settings? We explored the beneficial effects of a human probiotic against a human pathogen in infection-relevant environments and discovered few unexpected but translationally relevant findings.
A call for individual risk stratification on early morbidity and mortality in patients with newly diagnosed multiple myeloma
Behind the paper of „Predictors of early morbidity and mortality in newly diagnosed multiple myeloma: data from five randomized, controlled, phase III trials in 3700 patients” - an international team effort from the HOVON, EMN and GMMG study groups.