Influenza viruses cause acute respiratory infections and affect 5-15% of the world’s population each year, making it one of the most pressing public health concerns. The breadth of protection offered by current seasonal influenza vaccines is very limited due to the antigenic changes in circulating influenza viruses. Therefore, developing more broadly protective, or “universal” influenza vaccines that also provides long-term immunity against divergent influenza virus strains is of high importance in mitigating disease brought on by seasonal epidemics and the occasional pandemics.
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