TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD
Oncogene-TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD
Lipid Nanomachines Overcome Endo−Lysosomal Barrier
The presence of endo−lysosomal barrier limits the intracellular delivery of therapeutic biologics, but our lipid nanomachines bypass this barrier and improve the delivery efficiency regardless of the types of cargo and target cell.
What´s in blood ? EN-RAGE enters the stage
The pathophysiology of neuropsychiatric disorders is a complex web of events and the biological processes involved are not fully understood. We have studied the levels of blood immune modulators in first episode psychotic patients revealing changes in EN-RAGE that is produced by neutrophils.
Partner choice in social dilemmas can increase resource inequality
When individuals can choose with whom to cooperate, do they behave self-servingly and choose those who are ‘better off’? Or do they cooperate with others who are ‘worse off’, thereby helping others instead of themselves? We find that cooperation under partner choice can increase inequality.
Supporting alternative scientific approaches to assess global climate adaptation
In 2015, the Paris Agreement under the United Nations Framework Convention on Climate Change (UNFCCC) established the Global Goal on Adaptation (GGA), but using a very vague definition and without specifying how to assess progress towards it.
Metal-free Photoinduced C(sp3)–H/C(sp3)–H Cross-Coupling to access α‑Tertiary Amino Acid Derivatives
The cross-dehydrogenative coupling (CDC) reaction is the most efficient method for constructing α-tertiary amino acids (ATAAs). Here, we present a mild, metal-free CDC reaction for the construction of ATAAs with good yields and regioselectivity.