Behind the paper

Share the real story behind your paper, from conception to publication, the highs and the lows.

Contributor Nature Microbiology

Measuring the unmeasurable: modelling pathogen load dynamics to elucidate mechanistic determinants of host–Plasmodium falciparum interactions

5 years ago we decided to try to work out how the parasite load we see in human malaria patients is determined by parasite multiplication rate, parasite growth inhibition by the host response, and duration of infection. The big problem was that in humans with naturally acquired malaria we cannot measure any of these directly. Our attempts to solve the problem took us back in time to data generated almost 100 years ago, then forwards to discover novel mechanisms of host defense against malaria.
Go to the profile of Aubrey Cunnington
Jun 17, 2019
Contributor ISME J

How do diatoms acclimate and adapt to changing temperatures?

Each phytoplankton species has its own characteristic thermal performance curve. For most species, growth rate increases gradually with increasing temperature until a critical temperature is reached, and then growth rate drops quickly with further increases in temperature. Right now, most researchers assume that individual species thermal response curves will stay fixed, so temperature increases will change the biogeographic distributions of species.​ To better understand how phytoplankton will respond to increasing ocean temperatures, we wanted to develop a mechanistic understanding of the effects of changing temperature on diatom metabolism.
Go to the profile of Yue Liang
Jun 11, 2019
Contributor Nature Comms

HPV circRNAs: Transformation with no end in sight

Although circular RNAs (circRNAs) are abundant and can be encoded by viruses, the function of most circRNAs remain unclear. We describe the discovery of circRNAs in human papillomaviruses (HPVs) including a circular E7 RNA (circE7). CircE7 is translated and required for transformation in cervical cancer cells, providing strong evidence that circRNAs can be translated and have important biological functions. Jiawei Zhao Richard Wang
Go to the profile of Richard C Wang
Jun 11, 2019
Contributor Microbiome

The gut microbiome following acute HIV-1 infection

To our knowledge, this is the most comprehensive prospective study investigating the longitudinal impact of acute HIV-1 infection in an HIV-1 hyperendemic area such as the Manhiça district in Mozambique. This unique study confirms and extends previous findings in non-human primate models and provides critical insights into the impact of infections in the gut microbiome as well as into the pathogenesis of HIV-1 infection.
Go to the profile of Muntsa Rocafort Junca
Jun 05, 2019