Behind the paper

Share the real story behind your paper, from conception to publication, the highs and the lows.

Contributor Nature Microbiology

Measuring the unmeasurable: modelling pathogen load dynamics to elucidate mechanistic determinants of host–Plasmodium falciparum interactions

5 years ago we decided to try to work out how the parasite load we see in human malaria patients is determined by parasite multiplication rate, parasite growth inhibition by the host response, and duration of infection. The big problem was that in humans with naturally acquired malaria we cannot measure any of these directly. Our attempts to solve the problem took us back in time to data generated almost 100 years ago, then forwards to discover novel mechanisms of host defense against malaria.
Go to the profile of Aubrey Cunnington
Jun 17, 2019
Contributor ISME J

How do diatoms acclimate and adapt to changing temperatures?

Each phytoplankton species has its own characteristic thermal performance curve. For most species, growth rate increases gradually with increasing temperature until a critical temperature is reached, and then growth rate drops quickly with further increases in temperature. Right now, most researchers assume that individual species thermal response curves will stay fixed, so temperature increases will change the biogeographic distributions of species.​ To better understand how phytoplankton will respond to increasing ocean temperatures, we wanted to develop a mechanistic understanding of the effects of changing temperature on diatom metabolism.
Go to the profile of Yue Liang
Jun 11, 2019