July 2016 cover
Host Factor Expropriation for Viral Replication and Evasion. Image by Yang Luo and Mark Muesing, cover design by Karen Moore
HIV relies on a variety of cellular proteins to proliferate and persist in infected individuals. In an infected cell, the oligomeric HIV-1 envelope protein (red) recruits different sets of cellular interactors during the extensive maturation from its synthesis in the endoplasmic reticulum (green), through elaborate glycosylation in the Golgi (red; orange in combined) to its destination at the plasma membrane, the site of its incorporation on nascent virions.
Refers to HIV–host interactome revealed directly from infected cells by Luo et al.
Nature Microbiology, 1, 16068 (2016)