September 2016 cover
Cryo EM structure of Ebola Virus sGP. Image by Charles D. Murin, Ward lab, cover design by Karen Moore
Depicted on the cover is the cryo EM structure of Ebola Virus sGP, a non-structural protein that is secreted abundantly by infected cells. Both the dimeric sGP and the trimeric glycoprotein attached to the virus arise from a single gene, but form different oligomeric structures and present antibody epitopes uniquely. These structures extend our knowledge of the accessible filovirus immunogenic landscape.
Refers to Structures of Ebola virus GP and sGP in complex with therapeutic antibodies by Pallesen et al.
Nature Microbiology, 1, 16128 (2016)