The way to prevent antibiotic resistance

One of the ways in which the bacteria are respond to antibiotics is prevention of biofilm formation.

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In study carried out by Prof. Shakibaie MR and his colleagues they found that antibiofilm activity of a compound is directly related to expression of rhl operon in P. aeruginosa.  They research  published in Burns journal indicated the over-expression of rhlr quorum sensing regulatory gene decrease the amount of  antibiofilm activity of antimicrobial compounds.

Mohammad reza Shakibaie

Professor and senior research scientist at kerman university of medical sciences, Kerman University of Medical Sciences

M.R. Shakibaie earned his PhD from University of Pune India from 1992 to 1997. His thesis was lecular genetics of Plasmid Mediated Silver and Antibiotic Resistances in Acinetobacter baumannii”. He completed one year Postdoctoral research training at Aquatic Microbial Lab in Mysore, India during 2006. His research title was Horizontal Gene Transfer in Gram Negative Bacteria. Dr. Shakibaie Joined the Department of Microbiology, Kerman University of Medical Sciences in 1998. He has published more than 45 original research papers in different International peer reviewed journals with high impact factors in microbiology and biotechnology. The total impact factor of his research is more than 68, with h-index 11 and i10-index 12. His work is cited more than 296 times ( The research gate score index is 21.85. His work also has been cited in 3 textbooks of microbiology published from USA and Europe. He has presented more than 42 papers in International and National Conferences. He has made fundamental contributions in the area of gene transfer, plasmid biology, molecular microbiology, nanomicrobiology. He is on the editorial board of number of peer reviewed journals in Iran and abroad. He has successfully supervised 2 Ph.D., and 1 Post-Doctoral scholars for their research. Currently 2 Ph.D. students are working with him.