July 2017 cover

Linear ubiquitin recruitment to Salmonella mediates xenophagy and immune signaling. Image by Ella Maru Studio; cover design by Karen Moore.

Go to the profile of Michael Chao
Aug 02, 2017

Sending signals

Linear polyubiquitin patches in the Salmonella Typhimurium ubiquitin coat, regulated by E3 ligase LUBAC and deubiquitinase OTULIN, serve as a platform to modulate xenophagy, NF-kB signalling, secretion of pro-inflammatory cytokines and bacterial proliferation. 

Refers to "Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation" by van Wijk et al. 


"LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB" by Noad et al.

Nature Microbiology 2: 17066 (2017)

Nature Microbiology 2: 17063 (2017)

Go to the profile of Michael Chao

Michael Chao

Senior Editor, Nature Microbiology

I first developed an interest in bacterial pathogenesis while at Cornell University. I then earned my PhD in Biomedical and Biological Sciences from Harvard University in Eric Rubin’s laboratory, studying cell wall remodelling in Mycobacterium tuberculosis. From 2012-2015, I continued my training as a postdoctoral fellow in Matthew Waldor’s lab at Harvard Medical School, investigating the role of DNA methylation on regulating fundamental cellular processes in Vibrio cholerae.

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