A few too many…

A possible mechanism for alcohol-linked liver disease

Go to the profile of Heidi Burdett
Feb 12, 2016

We all know that too much alcohol is not exactly good for us, and excessive consumption can lead to a nasty bout of liver cirrhosis. A study published this week by Wang et al in Cell Host & Microbe provides more information on the effects of alcohol on the gut microbiota. Previous work has shown that chronic alcohol consumption is associated with reduced levels of antimicrobial-regenerating (REG)-3 lectins. Now, Wang and colleagues have linked this with an increase in mucosa-associated bacteria and bacterial translocation to the lymph nodes and liver of mice, “promoting the progression of ethanol-induced fatty liver disease toward steatohepatitis”. Yikes.

Something to discuss over Friday night drinks, perhaps?!

Go to the profile of Heidi Burdett

Heidi Burdett

Editor, Nature Microbiology

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