About Klaus Eyer
Immune responses are highly dynamic, heterogenous and their successful completion involves and needs many different interactions, cells and functions throughout the organism. Individual cells are the functional units within any immune response, and their varying frequencies and degrees of activity shape and define the reponse. Therefore, the state, activation and ultimately functionality of immune cells displays high dynamic heterogeneity, and hence there is a need for quantitative high-throughput systems that allow for a dynamic and functional single-cell phenotyping, linking function to the individual cells. In this regard, my research group focuses on developing and applying technologies and analytical strategies that allow us to measure, describe and exploit functionality within the immune system, resolved down to the individual, primary cell, to study novel and unique research questions. While doing ex vivo measurements, we are aiming to understand the functionalities of the extracted cells in vivo, within the context of our applied disturbance – vaccination, infection or malignant transformation.