Sibel Ebru Yalcin

Research Faculty, Yale University
  • Yale University
  • United States of America

About Sibel Ebru Yalcin

I am a physicist and spectroscopist who specializes in biological imaging. I have performed chemical imaging-based multimodal nanospectroscopy on biological molecules and environmental materials under their physiologically relevant conditions such as pH and humidity. My structural studies led to the discoveries of atomic structure of conductive “Geobacter” OmcS nanowires (Cell, 2019) and electric field stimulated production of 1000 times more conductive OmcZ nanowires (Nature Chemical Biology, 2020). Discovery of cytochrome OmcZ nanowires explains the mystery of high biofilm conductivity scientists observed even in the absence of cytochrome OmcS! Proteopedia selected Geobacter’s microbial cytochrome nanowires as the most influential structure discovered in the 21st century. Other than biological systems, I have performed the first Nanoscale Chemical Imaging on reactive minerals (Gibbsite, Lepidocrocite) through their water binding chemistry. My studies are critical to understand how mineral morphology plays key role on water chemistry (Science Advances, 2020). I have considerable experiences in Ultrafast Spectroscopy and Nanoscale Near-field Imaging of many low dimensional systems. At Los Alamos National Laboratory (LANL), I have built single molecule spectroscopy setup to study Carbon Nanotubes (Nanoscale, 2015) with Steve Doorn and other low dimension materials such as Graphene Oxide (ACS Nano, 2015), MoS2 (Nature Materials, 2014) with Manish Chhowalla. At University of Massachusetts Amherst, I have developed an Electrostatic Force Microscopy (EFM) based imaging method that has enabled the first visualization of electron transport in individual bacterial protein nanowires under biologically relevant conditions (Nature Nanotechnology, 2014) with Nikhil Malvankar & Derek Lovley. Currently I am a research faculty at Yale’s Department of Molecular Biophysics & Biochemistry and Microbial Sciences Institute. I lead the nanoscale functional imaging research to understand structural, physical and biochemical components and pathways involved in biological electron transfer. I have PhD in Physics, and extensive experience in Biochemistry, Geochemistry and Microbiology.


Bacteria Biochemistry Biofilms Environmental microbiology Infectious diseases